Many hematologic malignancies carry characteristic chromosomal translocations. Correct identification of fusion genes can ensure an accurate diagnosis and prognosis is made and can assist in making treatment decisions, stratification, and disease monitoring. Current methodologies used to detect fusion genes can be laborious and time-consuming, typically involving karyotyping, followed by fluorescence in situ hybridization (FISH) and molecular analysis based on reverse transcriptase polymerase chain reaction (RT-PCR).
Leukemia FusionOne Panel Kit is a qualitative in vitro diagnostic test for screening 52 fusion genes resulting from chromosome translocations involved in chronic and acute leukemia and leukemia-associated genes EVI1, HOX11, and HOX11L2.
All 52 genes include more than 182 clinically relevant chromosomal breakpoints. The kit detects RNA transcripts of the 52 leukemia-associated genes extracted from human bone marrow or whole blood samples using a RT-qPCR procedure. The kit results allow professionals to be more aware of the patient`s prognosis and provide professionals with essential insights into treatment planning.
Genes | 52 genes:
MLL-AF9, AML1-ETO, MLL-AF4, TEL-AML1, E2A-PBX1, MLL-ENL, SIL-TAL1, MLL-AF10, CBFβ-MYH11, AML1-MDS1/EV11, FIP1L1-PDGFRA, SET-CAN, E2A-HLF, DEK-CAN, MLL-SEPT6, TLS-ERG, TEL-PDGFRB, MLL-ELL, MLL-AF17, NPM-RARα, NPM-MLF1, PLZF-RARα, MLL-AF1q, MLL-AF1P, TEL-ABL1, AML1-MTG16, AML1-EAP, MLL-AF6, EVI1, BCR-ABL1 p190, BCR-ABL1 p210, PML-RARα S, PML-RARα V, PML-RARα L, CALM-AF10, HOX11, TEL-JAK2, MLL-AFX1, ETV6-PDFGRA, HOX11L2, dup MLL, NUP98-PMX1, NUP98-HOXD13, NUP98-HOXA9, NUP98-HOXA13, NUP98-HOXC11, NUP98-HOXA11, STAT5-RARα, NUMA-RARα, FIPIL1-RARα, PRKAR1A-RARα, NPM-ALK. |
---|---|
Sample types | Bone marrow, peripheral blood, FFPE, and cell lines |
Reaction Volume | 20 ul |
Reaction time | 3 hour |
Internal control | GUSB as housekeeping genes, 2 positive control, 3 negative control |
Sensitivity | 10-4 |
Instruments | Compatible with Bio-Rad CFX96, iCycler, ABI7500, Stratagene Mx3000P/Mx3005P, and other commonly used RT-qPCR machines. |
Cat. No. | Description | Size |
1-100-12020 | Leukemia FusionOne Panel Kit | 20-reactions |
The Leukemia FusionOne Panel Kit is a CE-marked product for In Vitro Diagnostic Use.
The Leukemia FusionOne Panel Kit is not FDA-cleared.
The FusionOne Panel offers customization options to ensure it perfectly aligns with your specific requirements.
Whether you need to focus on a niche genetic signature or broaden the panel’s capabilities, our customization options provide the flexibility you need without sacrificing performance or affordability.
A customized FusionOne Panel provides the perfect balance of precision, efficiency, and flexibility, tailored to meet the demands of your unique research or clinical goals. Its ability to adapt to evolving scientific needs ensures that it remains a valuable tool for laboratories, pharmaceutical companies, and healthcare institutions alike.
Contact us today to discuss your requirements and create the perfect solution for your needs!
Please contact us for a quote or with any questions about our products.
There are no products |